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To our knowledge, only one harmful inactivating FSHR mutation has been identified in men so far. Hormonal Control of Human Reproduction. This is to be compared with the dramatically elevated levels of fsh and lh in sperm development FSH observed in the absence of all testicular feedback signals in castrate or hypogonadal men Clomiphene in treatment of male infertility due to isolated follicle-stimulating-hormone deficiency. However, the quantitatively incomplete recovery of spermatogenesis in these mice emphasizes the importance of T for qualitatively and quantitatively full spermatogenesis. Modified from Goericke-Pesch.